2
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83729 |
Tat-CIRP TFA
Tat-Cold-inducible RNA Binding Protein |
||
Tat-CIRP是一种肽类抑制剂,用于抑制髓样分化2蛋白(MD-2,亦称淋巴细胞抗原96 [LY96])与寒冷诱导的RNA结合蛋白(CIRP)之间的蛋白-蛋白相互作用。它通过与MD-2结合,干扰MD-2与CIRP之间的相互作用,这一作用在共免疫沉淀实验中得到证实。在体内实验中,Tat-CIRP (10及20 mg/kg) 能够减少由中脑动脉闭塞(MCAO)引发的小鼠脑梗死体积。同样,在通过血栓引发脑梗死的恒河猴模型中,Tat-CIRP同样能减少脑梗死体积,并缩短患中风一侧手臂抓取并放下食物的时间。 | |||
T80154 |
TAT-CIRP
|
||
TAT-CIRP为小肽,指Tat融合的冷诱导RNA结合蛋白。作为骨髓分化蛋白2(MD2)的抑制剂,该化合物对小鼠缺血性及出血性中风显示出显著的神经保护效果。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03983 |
CIRBP Protein, Human, Recombinant (His)
cold inducible RNA binding |
Human | E. coli |
CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator.CIRBP can bind the 3 translated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for... | |||
TMPH-01110 |
CIRBP Protein, Human, Recombinant (GST)
A18HNRNP,CIRP,Glycine-rich RNA-binding |
Human | E. coli |
CIRBP Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPH-02587 |
CIRBP Protein, Mouse, Recombinant (His)
CIRP,A18 hnRNP,Glycine-rich RNA-binding |
Mouse | E. coli |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. |